N-Nitroso Compounds Occurrence and Biological Effects (Iarc Scientific Publications) by H. Bartsch

Cover of: N-Nitroso Compounds | H. Bartsch

Published by IARC Scientific Publications .

Written in English

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Subjects:

  • Oncology,
  • Chemistry - Organic,
  • Medical,
  • Science

Book details

The Physical Object
FormatHardcover
Number of Pages804
ID Numbers
Open LibraryOL9668801M
ISBN 100197230415
ISBN 109780197230411

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Discusses mechanisms of N-nitroso compound formation and denitrosation. Reviews the metabolism of nitrosamines and the modification of DNA and proteins by the products of metabolism.

Examines the effects of dietary components and other chemopreventive agents on N-nitroso compound metabolism and carcinogenicity. Discusses the use of specific biomarkers of nitrosamine exposure in humans and 5/5(2). N-Nitroso Compounds (Acs Symposium Series) Hardcover – January 1, by Steven Scanlan, Richard; Tannenbaum (Author)Author: Steven Scanlan, Richard; Tannenbaum.

Originally published inthis volume looks in depth at the carcinogenic properties of N-nitroso compounds. These compounds occur widely in smoked foods and in meat and fish cured with nitrates; they are also formed in N-Nitroso Compounds book industrial processes and in Cited by: Genotoxicology of N-Nitroso Compounds (Topics in Chemical Mutagenesis) Softcover reprint of the original 1st ed.

: Frederick Serres. Nitrates, nitrites, and N-nitroso compounds (Environmental health criteria) on *FREE* shipping on qualifying offers. Nitrates, nitrites, and N-nitroso compounds (Environmental health criteria)Format: Hardcover.

The purpose of the present volume is to attempt to organize and compare the genotoxic properties of the N-nitroso compounds. This is a particularly interesting class of compounds because of the problems encountered with the Salmonella assay of Ames in generating both.

Abstract The N -nitroso compounds fall into the category of carcinogens discovered through proposed industrial use (Barnes ).

In the early s the then Director of the Medical Research Council’s Toxicology Research Unit, the late Dr. J.M. Barnes, was asked by Dr. by: No part of this book may be reproduced in any form without the permission.

(N-nitroso compounds), (acrylamide) and (aflatoxin) of this Report. Biomarkers of health effects. N-Nitroso compounds were known almost 40 years ago to be present in food treated with sodium nitrite, which made fish meal hepatotoxic to animals through formation of nitrosodimethylamine (NDMA).

Since that N-Nitroso Compounds book, N-nitroso compounds have been shown in animal experiments to be the most broadly acting and the most potent group of by: N-nitroso compounds (NOCs) are found in processed meat and are formed endogenously from intake of nitrite and nitrate.

Endogenous NOC formation is antagonized by nitrosation inhibitors in fruit and vegetables (e.g., vitamin C) and promoted by heme in red by:   Keywords: N-nitroso compounds, colorectal cancer, vitamin C, vitamin E, effect-modification, case-control study Introduction Colorectal cancer (CRC) is one of the most serious types of N-Nitroso Compounds book health problems in North America, but its incidence rates vary geographically (1 ; 2).Cited by: The Health Effects of Nitrate, N-Nitroso Compounds book, and N- Nitroso Compounds: Part 1 of a 2-part Study, Assembly of Life Sciences (U.S.).

Part 1 of The Health Effects of Nitrate, Nitrite, and N-nitroso Compounds: Study by the Committee on Nitrite and Alternative Curing Agents in Food, Assembly of Life Sciences. Nitrosamides are chemical compounds that contain of the chemical structure R 1 C(=X)N(–R 2)–N=O, that is, a nitroso group bonded to the nitrogen of an amide or similar functional group.

Specific classes include the N-nitrosamides, N-nitrosoureas, N-nitrosoguanidines, and amides are usually chemically reactive, metabolically unstable, and often carcinogenic. Sources of nitrates, nitrites and n-nitroso compunds in air, water, soil, and food.

Transport and ptransformation inenvironmental and biological media. Environmental levels and exposures. Metabolism of nitrates, nitrites, and n-nitroso compounds.

Experimental animal studies on the effects of nitrates, nitrites, and n-nitroso. In book: Nitric Oxide Donors: For Pharmaceutical and Biological Applications, pp - In the presence of soil either parent compounds or N-nitroso derivatives are strongly adsorbed.

These. (source: Nielsen Book Data) Summary Presents recent advances in prevention of nitrosamine formation in vitro and in vivo. Discusses mechanisms of N-nitroso compound formation and denitrosation. Reviews the metabolism of nitrosamines and the modification of DNA and proteins by the products of metabolism.

N-Nitroso-N-methyl-N'-nitroguanidine (MNNG) is used as a standard carcinogen for the induc-tion of stomach and gut tumors in various animal species. DOSAGE IN LONG-TERM EXPOSURE The doses of N-nitroso compounds needed to in- duce tumors are low to very by: 5. You are here: Home / Book and Report Series / IARC Scientific Publications / N-Nitroso Compounds: Analysis, Formation and Occurrence.

N-Nitroso Compounds: Analysis, Formation and Occurrence IARC Scientific Publication No. Edited by Walker EA, Griciute L, Castegnaro M, Borzsonyi M. ISBN (Print Book) N-nitroso compounds are recognized as important dietary te assessment of N-nitroso intake is fundamental to advancing research regarding its role with us studies have not used a quantitative database to estimate their intake.

To address this gap a database of N-nitroso values was developed in conjunction with an existing food frequency questionnaire (FFQ).Cited by: N-nitroso compounds result from reactions involving other chemicals called alkylamines.

At room temperature, N-nitroso compounds are yellow liquids. They do not have a distinct odor. Industry makes small amounts of N-nitroso compounds for research.

They can also be formed as a side-reaction when other products are made. COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus.

N-Nitroso compounds were known almost 40 years ago to be present in food treated with sodium nitrite, which made fish meal hepatotoxic to animals through formation of nitrosodimethylamine (NDMA).Since that time, N-nitroso compounds have been shown in animal experiments to be the most broadly acting and the most potent group of key role of nitrite and nitrogen oxides in forming Cited by: You are here: Home / Book and Report Series / IARC Scientific Publications / N-Nitroso Compounds: Analysis and Formation.

N-Nitroso Compounds: Analysis and Formation IARC Scientific Publication No. Edited by Bogovski P, Preussman R, Walker EA.

ISBN (Print Book) The International Agency for Research on Cancer (IARC) has published a number of conference proceedings which have dealt with the occurrence, formation, analysis and biological effects of N-nitroso compounds, principally nitrosamines and nitrosamides []. There was something of an explosion of interest and research work in all of these areas.

Presents recent advances in prevention of nitrosamine formation in vitro and in vivo. Discusses mechanisms of N-nitroso compound formation and denitrosation. Reviews the metabolism of nitrosamines and the modification of DNA and proteins by the products of metabolism.

Examines the effects of dietary components and other chemopreventive agents on N-nitroso compound. The questions of whether and how N-nitroso compounds (NOC) may be inducing cancer in humans are principal subjects covered include nitrite-derived alkylating agents that are not NOC, reasons for the wide tissue specificity of carcinogenesis by NOC, the acute toxicity of nitrosamines in humans, mechanisms of in vivo formation of NOC by chemical and bacterial nitrosation in the Cited by: The levels of tobacco-specific nitrosamines (TSNA), N-nitrosodiethanolamine, volatile and non-volatile N-nitroso compounds in zarda, a partially fermented Indian tobacco product are presented.

Total identified N-nitroso compound concentrations ranged from to mg/kg fresh weight tobacco, TSNA accounted for 76–91 % of the total N-nitroso Cited by: Unfortunately, this book can't be printed from the OpenBook. If you need to print pages from this book, we recommend downloading it as a PDF.

Visit to get more information about this book, to buy it in print, or to download it as a free PDF. The Health Effects of Nitrate, Nitrite, and N-Nitroso Compounds: Part 1 of a 2-Part Study Get This Book MyNAP members save 10% online. Login or Register to save.

This book attempts to demonstrate the complexity of the mechanisms of biological action of the toxic N-nitroso compounds. The conclusions presented on genetic toxicology are based on comparative studies of biological assays and a firm foundation of chemical structural relations among N-nitroso compounds.

The remaining N-nitroso compounds excreted in urine and those present in faeces are still unidentified. A crude mass balance between exogenous exposure and excretion in urine and faeces indicates that % of the total human exposure to N-nitroso compounds results through in vivo by: Nitrosamines are organic compounds of the chemical structure R 2 N–N=O, where R is usually an alkyl group.

They feature a nitroso group (NO +) bonded to a deprotonated amine. Most nitrosamines are. You are here: Home / Book and Report Series / IARC Monographs on the Identification of Carcinogenic Hazards to Humans / Some Inorganic Substances, Chlorinated Hydrocarbons, Aromatic Amines, N-Nitroso Compounds, and Natural Products.

Open Library is an open, editable library catalog, building towards a web page for every book ever published. Nitrosamines and related N-nitroso compounds by,American Chemical Society edition, in English.

About this book Proceedings of the VIIIth International Symposium on N-Nitroso Compounds, held in Banff, Canada, September Rights & Permissions. IARC Working Group on the Evaluation of the Carcinogenic Risk of Chemicals to Humans: Some N-Nitroso Compounds.

Some N-nitroso compounds. Geneva: World Health Organization, (OCoLC) Online version: IARC Working Group on the Evaluation of the Carcinogenic Risk of Chemicals to Humans: Some N-Nitroso Compounds.

Some N-nitroso compounds. In addition, the presence of less volatile and non-volatile N-nitroso compounds or their precursors in foods have been suggested from a number of model system studies. This paper reviews the possible formation of these compounds in selected food products.

Originally published inthis volume looks in depth at the carcinogenic properties of N-nitroso compounds. These compounds occur widely in smoked foods and in meat and fish cured with nitrates; they are also formed in some industrial processes and in. Some Aromatic Amines, Hydrazine and Related Substances, N-Nitroso Compounds and Miscellaneous Alkylating Agents IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 4.

IARC. ISBN (Print Book) Organic Chemistry Book: Basic Principles of Organic Chemistry (Roberts and Caserio) Organonitrogen Compounds I- Amines {N}\)-nitroso compounds while tertiary arenamines undergo electrophilic substitution with \(\ce{NO}^\oplus\) if they have an unsubstituted para position: C Diazo Coupling Reactions.

N-Nitrosoglyphosate is a degradation product and synthetic impurity of glyphosate herbicide. The US EPA limits N-nitrosoglyphosate impurity to a maximum of 1 ppm in glyphosate formulated products.

[citation needed] N-Nitrosoglyphosate can also form from the reaction of nitrates and ion of N-nitrosoglyphosate has been observed in soils treated with sodium nitrite .

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